Jonny Walker, Alex Thompson and Stephen Wild will all retire from rugby league at the end of the 2019 season.
Crusaders’ clash with London Skolars at Queensway Stadium on Saturday, September 7 will be the last game in a red shirt for all three players.
Walker, who has been at North Wales since they formed back in late 2011, currently holds the club’s record for the most appearances, having turned out 167 occasions.
Thompson, meanwhile, has scored 23 tries in 58 appearances since joining the Wrexham club ahead of the 2015 campaign.
Wild, who was capped for Great Britain and England earlier in his career and spent the best part of the decade in Super League, has been a real leader out on the pitch for the club since 2014.
Crusaders head coach Anthony Murray: “All three players have had fantastic careers and we’ll be sorry to lose them.
“Jonny has been with Crusaders since the very start and the amount of effort he has put in for the club shows exactly what we’re all about.
“He’ll give you more than 100 per cent every time he goes out on the pitch and he’s been a big part of what the club have achieved over the years.
“Alex has been a pleasure to work with and, when he’s on form, you can see the effect he has on the rest of the team.
“He’s another player who it’s clear it means a lot to when he wears the Crusaders shirt.
“Stephen is an ultimate professional and the leadership qualities he shows out on the pitch are second to none.
“He came to the club after playing at the highest level for many years and his experience has been crucial for us ever since.
“It would be great to see plenty of fans get down to Queensway, enjoy the game and give these lads the send off they deserve.”
North Wales’ final home match of the season against Skolars is doubling up as a Family Fun Day, with entry priced at just £12 for adults, £10 for concessions and free for U16s.